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Common drugs linked to C. diff risk, study

“Given their high prevalence and strong associations with CDI, our findings underscore the importance of prudent prescribing and regular medication review."

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    A Swedish study found that many commonly prescribed drugs, beyond antibiotics, increase the risk of Clostridioides difficile infection (CDI).

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    Antibiotics posed the highest risk, with lincosamides showing 31 times the odds of CDI compared to controls.

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    Nonantibiotic medications such as antidiarrheal agents, corticosteroids, and analgesics were also linked to increased CDI risk.

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    The study highlighted the need for careful prescribing practices due to the strong associations between medications and CDI.

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    Limitations included potential reverse causation and lack of data on hospital and over-the-counter medications.